When choosing a joint support supplement you will be confronted with an array of choices. There's various combinations of glucosamine, chondroitin, and MSM. Glucosamine and chondroitin come in two different flavors: sulfate or hydrochloride. These refer to the anion that is associated with the main glucosamine/chondroitin molecule.
We believe that the sulfate form of these ingredients is better because the individual components of cartilage are glycosaminoglycans which contain sulfate. No studies have been done comparing the efficacy of supplementation using the sulfate form versus the hydrochloride form. However, based on the molecular structure of cartilage consisting mostly of chondroitin SULFATE and keratin SULFATE we believe it was a better choice to source the sulfate form of these raw materials.